Relationship between lower number of oocytes retrieved and clinical outcomes of in vitro fertilization-embryo transfer

被引:0
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作者
王雪梅 [1 ]
姜宏 [2 ]
张文香 [2 ]
魏兆莲 [3 ]
机构
[1] Reproductive Medicine Center,Clinical College of PLA,Anhui Medical University
[2] Reproductive Medicine Center,the 105~(th) Hospital of PLA
[3] Department of Reproductive Medicine Center,Obstetrics &.Gynecology Department,the First Affiliated Hospital of Anhui Medical University
关键词
In vitro fertilization-embryo transfer; Age; Controlled ovarian hyperstimulation; Number of retrieved oocytes; Clinical outcomes;
D O I
暂无
中图分类号
R714.8 [];
学科分类号
100211 ;
摘要
Objective:To explore the clinical outcomes of the infertile women with retrieved oocytes less than or equal to 5 undergoing in vitro fertilization-embryo transfer(IVF-ET) or intracytoplasmic sperm injection(1CSI). Methods:The clinical data of 216 embryo transfer cycles with retrieved oocytes less than or equal to 5 during the procedure of IVF/ICSI in Reproductive Medicine Center of the 105;Hospital of PLA from Jul.2008 to Dec.2011 were analyze retrospectively.All the patients were divided into group A(< 35 years),group B(35-39 years) and group C(≥40 years) according to the ages,and 409 IVF/ICSI cycles with patients’ age less than 35 years old and 6-15 retrieved oocytes in the same period were served as controlled group.Then the patients≥35 years were subdivided into gonadotropin-releasing hormone agonist(GnRH-a) long protocol group,GnRH-a short group and GnRH antagonist group according to the protocols of controlled ovarian hyperstimulation(COH).The clinical date and the outcomes were analyzed and compared among all groups. Results:There were significantly differences in clinical pregnancy rate(38.3%vs.19.4%) and early abortion rate(16.1%vs.50.0%) between group A and group C(P<0.05),and there were no significant differences in clinical pregnancy rate(38.3%vs.41.6%)and early abortion rate(16.1%vs.10.0%) between group A and control group(P>0.05).There were no significant differences in clinical pregnancy rates(29.01%vs.26.1%vs.25.9%) and early abortion rates(33.3%vs.33.3%vs.40.0%) among GnRH-a long protocol group,GnRH-a short group and GnRH antagonist group(P>0.05). Conclusions:Relatively satisfactory clinical outcomes of IVF/ICSI would still be got for the patients <35 years with retrieved oocytes less than or equal to 5,but whatever COH protocols such as GnRH-a long protocol,GnRH-a short and GnRH antagonist could not improve the outcomes of IVF/ICSI for the patients aged≥35 with retrieved oocytes less than or equal to 5.
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页码:36 / 41
页数:6
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