BACKGROUND AND OBJECTIVE Open label studies of patients with Alzheimer’disease(AD)dementia treated with IVIG therapy have found evidence of modest cognitive improvement.This study was designed to determine whether a short treatment course of IVIG,given at the mild cognitive impairment(MCI)stage of AD,can reduce rates of brain atrophy,cognitive decline and/or conversion to AD dementia.METHODS Subjects were patients 50 to 84 years of age diagnosed with amnesic MCI.At baseline,the patients underwent physical and