A Lewis acid-catalyzed tandem reaction enabling 2-arylglycerol derivative as a versatile 1,3-biselectrophile for the synthesis of 4H-chromenes and 2-pyridinones

被引：0

作者：

Shaomin Chen ^{[1
]}

Tianjian Zhang ^{[1
]}

Zhenhua Xu ^{[1
]}

Bo You ^{[1
]}

Minghao Li ^{[1
]}

Yanlong Gu ^{[1
,2
,3
]}

机构：

[1] Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure,School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology

[2] School of Chemistry and Chemical Engineering, The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University

[3] State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics

来源：

Chinese Chemical Letters | 2023年 / 34卷 / 09期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

O621.251 [];

学科分类号：

摘要：

Acid-catalyzed tandem reactions were established by employing a novel class of 2-arylglycerol derivative,5-aryl-1,3-dioxan-5-ol, as versatile 1,3-biselectrophile. In the reactions, 5-aryl-1,3-dioxan-5-ol works like atropaldehydes or 2-aryl malondialdehydes, and can react with 2-naphthols and β-keto amides, allowing the synthesis of 4H-chromenes and 5-aryl-2-pyridinones. High yields, good functional group tolerance,broad substrate scope and simple reaction operation make this protocol attractive.

引用

页码：165 / 168

页数：4

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