Total Synthesis of (-)-Tetrahydrolipstatin by the Tandem Mukaiyama-aldol Lactonization

被引：0
|
作者：
Jian YIN1
机构：
来源：
Chinese Chemical Letters | 2005年 / 11期
关键词：
Tetrahydrolipstatin; tandem Mukaiyama-aldol lactonization; asymmetric synthesis; (R)-β-hydroxy tetradecanal; resolution;
D O I：
暂无
中图分类号：
O621.3 [有机合成化学];
学科分类号：
070303 ; 081704 ;
摘要：
(-)-Tetrahydrolipstatin 1 was synthesized in three steps and 33.8% overall yield from aldehyde 6 by tandem Mukaiyama-aldol lactonization, which offered a concise, efficient and highly diastereoselective route to this antiobesity drug. We also presented a resolution method for preparation of the crucial intermediate, β- (t-butyldimethylsilyloxy)tetradecanal.
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页码：32 / 34
页数：3
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