Mitochondrial Ca2+ transport and permeability transition pore opening and mitochondrial energetic status

被引：0
|
作者：
黄行许
翟大勇
黄有国
杨福愉
机构：
[1] China
[2] National Laboratory of Biomacromolecules
[3] Beijing 100101
[4] Institute of Biophysics
[5] Chinese Academy of Sciences
来源：
Science China Life Sciences | 2000年 / 05期
关键词：
mitochondrial Ca2+ transport; permeability transition pore; electron transport; energy coupling;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The relationship between mitochondrial Ca2+ transport and permeability transition pore (PTP) opening as well as the effects of mitochondrial energetic status on mitochondrial Ca2+ transport and PTP opening were studied. The results showed that the calcium-induced calcium release from mitochondria (mClCR) induced PTP opening. Inhibitors for electron transport of respiratory chain inhibited mClCR and PTP opening. Partial recovery of electron transport in respiratory chain resulted in partial recovery of mClCR and PTP opening. mClCR and PTP opening were also inhibited by CCCP which eliminated transmembrane proton gradient. The results indicated that mitochondrial Ca2+ transport and PTP opening are largely dependent on electron transport and energy coupling.
引用
收藏
页码：489 / 497
页数：9
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