In the process of business communication,there are many factors that determine and influence the communication and results. Cultural factors could become the key to the exchange effect. Cultural factors not only refer to the different cultural backgrounds of the two sides,but also refer to the cultural connotations embodied in the communication. Sorting out the cultural impact of business communication will be undoubtedly a tremendous promotion to conduct commercial exchanges. In this paper,through the analysis on the cultural impact of business communication,I give some thoughts on how to use culture to serve business communication.