Plasma Epstein-Barr virus DNA as a biomarker for nasopharyngeal carcinoma

被引：0
|
作者：
K.C.Allen Chan
机构：
[1] Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
[2] Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital
[3] State Key Laboratory in Oncology in South China, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital
来源：
癌症 | 2014年 / 33卷 / 12期
关键词：
Plasma Epstein-Barr virus EBV DNA; tumor markers; nasopharyngeal carcinoma; cancer screening;
D O I：
暂无
中图分类号：
R739.63 [咽肿瘤];
学科分类号：
100214 ;
摘要：
Nasopharyngeal carcinoma(NPC)is common in southern China and Southeast Asia.Epstein-Barr virus(EBV)infection is an important etiology for NPC,and EBV genome can be detected in almost all tumor tissues of NPC in this region.Plasma EBV DNA,when quantitatively analyzed using real-time polymerase chain reaction(PCR),has been developed as a biomarker for NPC.In this review,the different clinical applications of plasma EBV DNA in the management of NPC,including screening,monitoring,and prognostication,are discussed.In addition,the biological issues of circulating EBV DNA,including the molecular nature and clearance kinetics,are also explored.
引用
收藏
页码：598 / 603
页数：6
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共 9 条
  • [1] Scanning for Cancer Genomic Changes in Plasma: Toward an Era of Personalized Blood-Based Tumor Markers[J] . K.C. Allen Chan.Clinical Chemistry . 2013 (11)
  • [2] Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program
    Chan, K. C. Allen
    Hung, Emily C. W.
    Woo, John K. S.
    Chan, Paul K. S.
    Leung, Sing-Fai
    Lai, Franco P. T.
    Cheng, Anita S. M.
    Yeung, Sze Wan
    Chan, Yin Wah
    Tsui, Teresa K. C.
    Kwok, Jeffrey S. S.
    King, Ann D.
    Chan, Anthony T. C.
    van Hasselt, Andrew C.
    Lo, Y. M. Dennis
    [J]. CANCER, 2013, 119 (10) : 1838 - 1844
  • [3] Long‐term survival analysis of nasopharyngeal carcinoma by plasma Epstein‐Barr virus DNA levels[J] . Wen‐Yi Wang,Chih‐Wen Twu,Hsin‐Hong Chen,Rong‐San Jiang,Ching‐Te Wu,Kai‐Li Liang,Yi‐Ting Shih,Chien‐Chih Chen,Po‐Ju Lin,Yi‐Chun Liu,Jin‐Ching Lin.Cancer . 2012 (5)
  • [4] Plasma Epstein-Barr Virus DNA Screening Followed by 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography in Detecting Posttreatment Failures of Nasopharyngeal Carcinoma
    Wang, Wen-Yi
    Twu, Chih-Wen
    Lin, Wan-Yu
    Jiang, Rong-San
    Liang, Kai-Li
    Chen, Kuan-Wen
    Wu, Ching-Te
    Shih, Yi-Ting
    Lin, Jin-Ching
    [J]. CANCER, 2011, 117 (19) : 4452 - 4459
  • [5] Different Clinical Significance of Pre- and Post-treatment Plasma Epstein–Barr Virus DNA Load in Nasopharyngeal Carcinoma Treated with Radiotherapy[J] . Xue Hou,Chong Zhao,Ying Guo,Fei Han,Li-Xia Lu,Shao-Xiong Wu,Su Li,Pei-Yu Huang,He Huang,Li Zhang.Clinical Oncology . 2010 (2)
  • [6] Relationship between pretreatment level of plasma Epstein-Barr virus DNA, tumor burden, and metabolic activity in advanced nasopharyngeal carcinoma[J] . Brigette B.Y. Ma,Ann King,Y.M. Dennis Lo,Y.Y. Yau,Benny Zee,Edwin P. Hui,Sing F. Leung,Frankie Mo,Michael K. Kam,Anil Ahuja,Wing H. Kwan,Anthony T.C. Chan.International Journal of Radiation Oncology, Biology, Physics . 2006 (3)
  • [7] Nasopharyngeal carcinoma
    Wei, WI
    Sham, JST
    [J]. LANCET, 2005, 365 (9476): : 2041 - 2054
  • [8] Circulating EBV DNA as a tumor marker for nasopharyngeal carcinoma
    Chan, KCA
    Lo, YMD
    [J]. SEMINARS IN CANCER BIOLOGY, 2002, 12 (06) : 489 - 496
  • [9] Prognostic implication of pretreatment plasma/serum concentration of Epstein-Barr virus DNA in nasopharyngeal carcinoma
    Lo, YMD
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2001, 55 (07) : 362 - 365
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