Measurements and significance of serum gastrin,plasma motilin and serum beta-endorphin in patients with severe burns

To investigate the changes and significance of serum gastrin (GAS),betaendorphin (beta-EP) and plasma motilin (MTL) in patients with severe burns.Methods Blood samples were gotten according to different timepoints from 32 admitted burned patients,and then serum GAS,beta-EP and plasma MTL were determined by radio-immuno assay (RIA).Results In patients with severe burns,serum GAS decreased significantly in early period.And at the timepoint of 8 h,it reached the lowest level.But during 9-24 h it elevated for a while,and then it reached a relatively stable level.MTL reached the highest level at the timepoint of 2 h after burning.Then at the shock stage,it was comparatively lower.And at the timepoint of 8 h after burning,it reached the lowest level,then raised persistently after reabsorption,but still lower than the normal level.At the early stage after burning,beta-EP raised,then reached the highest level at 8 h after burning.GAS and MTL decreased and beta-EP increased significantly with the increase of the burned area.However,when the burned area was over 70% of the total body surface area,there was no relationship between then.Conclusion Blood GAS,MTL and beta-EP have represented regular changes in patients with severe burns at the early stage after burning.And the painstimulus and shock are effective factors.7 refs,3 tabs.