LincRNA-p21在癌症机制中的研究进展

被引：2
|
作者：
赵素月 [1 ]
朱克祥 [1 ,2 ]
李文军 [1 ]
李汛 [1 ,2 ]
机构：
[1] 兰州大学第一临床医学院
[2] 兰州大学第一医院普外科
来源：
肿瘤防治研究 | 2020年 / 47卷 / 10期
关键词：
lincRNA-p21; p53; 癌症;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
长链非编码RNA是一类不编码蛋白质的RNA,通过多种机制参与不同的生物学行为。lincRNA-p21是一种抑癌基因,并与p53密切相关。lincRNA-p21通过MDM2、ING1b和p21等多个靶标调节p53参与细胞周期、增殖、凋亡的调控,并通过HIF-1α协调Warburg效应参与细胞代谢等多种生物学作用。lincRNA-p21与肿瘤的预后和治疗密切相关。因此lincRNA-p21可作为癌症的诊断和预后的生物标志物。本文就lincRNA-p21生物学功能与在疾病中的作用机制作一简要综述。
引用
收藏
页码：802 / 806
页数：5
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