Numerical simulation of solid tumor angiogenesis with Endostatin treatment:a combined analysis of inhibiting effect of anti-angiogenic factor and micro mechanical environment of extracellular matrix

被引：3

作者：

蔡彦 ^{[1
]}

吴洁 ^{[1
]}

古娜 ^{[1
]}

张洪一 ^{[1
]}

曹金凤 ^{[1
]}

许世雄 ^{[1
]}

龙泉 ^{[2
]}

柯林斯 ^{[2
]}

机构：

[1] Department of Mechanics and Engineering Science,Fudan University

[2] Brunel Institute for Bioengineering,Brunel University,Uxbridge

来源：

Applied Mathematics and Mechanics(English Edition) | 2009年 / 30卷 / 10期

基金：

中国国家自然科学基金;

关键词：

tumor angiogenesis; anti-angiogenesis; mechanical environment; mathematical model;

D O I：

暂无

中图分类号：

R318.0 [一般性问题]; R730.5 [肿瘤治疗学];

学科分类号：

摘要：

To investigate the influence of anti-angiogenesis drug Endostatin on solid tumor angiogenesis, a mathematical model of tumor angiogenesis was developed with combined influences of local extra-cellular matrix mechanical environment, and the inhibiting effects of Angiostatin and Endostatin. Simulation results show that Angiostatin and Endostatin can effectively inhibit the process of tumor angiogenesis, and decrease the number of blood vessels in the tumor. The present model could be used as a valid theoretical method in the investigation of anti-angiogenic therapy of tumors.

引用

页码：1247 / 1254

页数：8

共 8 条

[1] Numerical simulation of solid tumor angiogenesis with Endostatin treatment: a combined analysis of inhibiting effect of anti-angiogenic factor and micro mechanical environment of extracellular matrix
Cai, Yan
Gulnar, Kalkabay
Zhang, Hong-yi
Cao, Jin-feng
Xu, Shi-xiong
Long, Quan
Collins, M. W.
APPLIED MATHEMATICS AND MECHANICS-ENGLISH EDITION, 2009, 30 (10) : 1247 - 1254
[2] Numerical simulation of solid tumor angiogenesis with Endostatin treatment: a combined analysis of inhibiting effect of anti-angiogenic factor and micro mechanical environment of extracellular matrix
Yan Cai
Jie Wu
Kalkabay Gulnar
Hong-yi Zhang
Jin-feng Cao
Shi-xiong Xu
Quan Long
M. W. Collins
Applied Mathematics and Mechanics, 2009, 30 : 1247 - 1254
[3] Numerical simulation of tumor angiogenesis under the effect of Endostatin:considering mechanical environment in matrix and inhibiting effect of anti-angiogenic factor
Kalkabay Gulnar
M.W.Collins
医用生物力学, 2009, 24 (S1) : 95 - 95
[4] Numerical simulation of tumor angiogenesis under the effect of Endostatin:considering mechanical environment in matrix and inhibiting effect of anti-angiogenic factor
Kalkabay Gulnar
MWCollins
医用生物力学, 2009, 24(S1) (S1) : 95
[5] Modeling the Interplay Between Pathological Angiogenesis and Solid Tumor Growth: the Anti-angiogenic Treatment Effect
Argyri, Katerina D.
Dionysiou, Dimitra D.
Stamatakos, Georgios S.
PROCEEDINGS OF THE 2012 5TH INTERNATIONAL ADVANCED RESEARCH WORKSHOP ON IN SILICO ONCOLOGY AND CANCER INVESTIGATION - THE TUMOR PROJECT WORKSHOP (IARWISOCI), 2012,
[6] Numerical simulation of inhibiting effects on solid tumour cells in anti-angiogenic therapy: application of coupled mathematical model of angiogenesis with tumour growth
Cai, Yan
Wu, Jie
Xu, Shi-xiong
Long, Quan
Yao, Wei
APPLIED MATHEMATICS AND MECHANICS-ENGLISH EDITION, 2011, 32 (10) : 1287 - 1296
[7] Numerical simulation of inhibiting effects on solid tumour cells in anti-angiogenic therapy: application of coupled mathematical model of angiogenesis with tumour growth
Yan Cai
Jie Wu
Shi-xiong Xu
Quan Long
Wei Yao
Applied Mathematics and Mechanics, 2011, 32 : 1287 - 1296
[8] Numerical simulation of inhibiting effects on solid tumour cells in anti-angiogenic therapy: application of coupled mathematical model of angiogenesis with tumour growth
蔡彦
吴洁
许世雄
龙泉
姚伟
Applied Mathematics and Mechanics(English Edition), 2011, 32 (10) : 1287 - 1296

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