The Erythropoietin Receptor: Dimerization and Intracellular Signal Transduction

被引：0

作者：

WU Hong Harvey F LodishWhitehead Institute for Biomedical Research Nine Cambridge Center Cambridge MA USA Department of Biology Massachusetts Institute of Technology Cambridge MA USA ^{[2142
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机构：

来源：

实验血液学杂志 | 1996年 / 03期

关键词：

erythropoietin erythropoietin receptor dimerization signal transduction;

D O I：

暂无

中图分类号：

R329 [人体组织学];

学科分类号：

摘要：

<正> Erythropoietin (EPO), a 34 kD glycopro-tein, is the principal growth factor regulating theproduction of circulating erythrocytes; EPO isessential for committed CFU - E erythroid pro-genitors to divide several times and then to dif-ferentiate into erythrocytes. Like most receptorsfor hematopoietic growth factors, the erythro-poietin receptor (EPO - R) is a type I trans-membrane protein and a member of the cytokinereceptor superfamily. These receptors containfour conserved cysteines and a Trp - Ser - X -

引用

页码：229 / 235

页数：7