PROGNOSTIC SIGNIFICANCE OF EXPRESSION OF SURVIVIN IN ACUTE LEUKEMIA

Objective: To investigate the expression of survivingene and its significance in acute leukemia. Methods:The expression of surviving in 134 acute leukemiapatients and 4 leukemia cell lines was detected byRT-PCR and immunofluorescence analysis. Results: We detected survivin expression in 78 of 134 acute leukemia patients and all the cell lines but not in normal controls and anemia patients. Survivin gene expressioncorrelated with a lower white blood cell count, whichwas 11?09/L and 48?09/L in the positive and negative group respectively (P<0.01 by the Mann-Whitney test). In 55 cases of FAB M1/M2/M3, it was associated withleukemic cell maturation(P<0.01 by the Fisher test).Survivin expression was strongly related to survival time of acute leukemia patients (P<0.05). Conclusion: These data suggest that survivin expression may be considered as a new unfavorable prognostic factor for acuteleukemia due to its important role in apoptosisinhibition that influences disease outcome.