Scrutinizing the causal relationship between schizophrenia and vitamin supplementation: a Mendelian randomization study

被引:0
|
作者
Fahira Aamir
Zhu Zijia
Li Zhiqiang
Shi Yongyong
机构
[1] Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education)
[2] Henan Province
[3] Department of Pharmacy
[4] Henan Key Laboratory of Precision Clinical Pharmacy
[5] Shanghai Jiao Tong University
[6] Bio-X Institutes
[7] Collaborative Innovation Center for Brain Science
[8] The First Affiliated Hospital of Zhengzhou University
基金
中国国家自然科学基金;
关键词
dietary intake; Mendelian randomization study; psychiatric disorders; unhealthy lifestyle; vitamins supplementation;
D O I
暂无
中图分类号
R749.3 [精神分裂症];
学科分类号
100205 ;
摘要
Objective: Observational studies have reported malnutrition and vitamin deficiency in patients with schizophrenia (SZ), which can lead to serious metabolic syndromes and decrease anti-psychiatric drug outcomes. Whereas, vitamin intake along with psychiatric medication can enhance the medication outcomes. However, it is still unknown if SZ induces vitamin deficiency. Herein, we conduct the Mendelian randomization analysis to explore the causal relationship between schizophrenia and vitamins supplementation.Methods: We retrieved the genome-wide summary statistical data for schizophrenia from recent SZ GWAS data (43,175 cases and 65,166 controls) and vitamins supplementation GWAS data from Neale’s GWAS datasets (more than 337,000 samples from the European population) and performed a two-sample Mendelian randomization analysis to determine the causal association of SZ with vitamin supplementation, in addition, we conduct the sensitivity analysis to obtain reliable results and remove confounding bias.Results: SZ have causal relationships with vitamins A, B, C, D, and E (SZ/vitamin A: β = 0.002, se= 0.001, 95% confidence interval (CI): 0.001 to 0.004,P= 1.41E-05, heterogeneityP= 0.4486; SZ/vitamin B: β= 0.004, se= 0.001, 95% CI: 0.002-0.005,P= 7.0E-05, heterogeneityP= 0.2217; SZ/vitamin C: β= 0.004, se= 0.001, 95% CI: 0.002-0.007,P= 0.001, heterogeneityP= 0.1349; SZ/vitamin D: β= 0.003, se= 0.001, 95% CI: 0.002-0.005,P= 0.001, heterogeneityP= 0.433; SZ/vitamin E: β= 0.003, se= 0.001, 95% CI: 0.002-0.005,P= 5.0E-05, heterogeneityP= 0.1382).Conclusion: Our findings suggest that vitamin levels and supplementation should be carefully controlled in patients with SZ, which in turn may enhance the therapeutic effects of antipsychotic drug treatments.
引用
收藏
页码:18 / 26
页数:9
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