SYNTHESIS OF THE RING—AND SIDE—CHAIN—14C—LABELED 1,2—BIS—(4—MORPHOLINOMETHYL—3,5—DIOXOPIPERAZIN—1—YL) PROPANE

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作者
杨正修
章辛
机构
[1] Shanghai Institute of Materia Medica Academia Sinica Shanghai 200031 China
[2] Shanghai Institute of Materia Medica Academia Sinica Shanghai 200031 China
关键词
Probimane; 1; 2-bis (4-morpholinomethyl-3; 5-dioxopiperazin-l-yl) propane 14C-labeled;
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摘要
The ring-and side-chain-C-labeled probimane, 1,2-bis (4-morpholinomethy1-3,5-dioxopiperazin-1-yl) propane were synthesized from acetic acid-1-C in 4 steps and fromC-formaldehyde in 1 step respectively. The radiochemical yeild for the ring labeling was 28.1%; for the side-chain labeling was 18.5%.
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页码:233 / 235
页数:3
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