条件性基因敲除动物及其在毒理学研究领域的应用进展

被引：2

作者：

胡红 ^{[1
,2
]}

李子南 ^{[1
]}

郑珊 ^{[1
]}

敬海明 ^{[1
]}

冯颖 ^{[1
]}

尤育洲 ^{[1
]}

李国君 ^{[1
,2
]}

宁钧宇 ^{[1
,2
]}

机构：

[1] 北京市疾病预防控制中心/北京市预防医学研究中心食物中毒诊断溯源技术北京市重点实验室

[2] 首都医科大学公共卫生学院

来源：

实验动物科学 | 2018年 / 35卷 / 02期

关键词：

条件性基因敲除动物; 毒理学机制; 毒理基因组学;

D O I：

暂无

中图分类号：

R-332 [医用实验动物学]; R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

动物实验是毒理学研究中的重要手段和核心内容。传统的基因敲除动物在胚胎致死性基因研究方面具有一定局限性。条件性基因敲除动物在克服传统基因敲除动物缺陷的情况下,为更深、更广的毒理学研究提供了重要工具。本文将从条件性基因敲除技术的原理及条件性基因敲除动物在毒理学领域中的应用进展两方面来进行综述。

引用

页码：79 / 84

页数：6

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