Low-dose oral cyclophosphamide therapy is effective for condylomata acuminata

To the editor:Condylomata acuminata（CA）caused by human papillomavirus（HPV）,typically types 6 and 11,is a common sexually transmitted disease.Multiple physical treatments applied against CA are all invasive therapies and associated with high recurrence rates.Alternatively,immune-based therapy is considered as a new direction against CA.Nevertheless,the ideal immune-based therapy still remains undetermined.Cyclophosphamide（CY）is an alkylating agent widely used in the treatment of malignancies as well as autoimmune disorders.It now becomes clear that low-dose CY selectively reduces CD4;FoxP3;regulatory T（Treg）cells and restores the efficiency of immune responses.;We previously demonstrated the clinical efficacy of low-