Efficacy and safety of micafungin for invasive Candida infections:a meta-analysis of randomized controlled trials

Background Invasive fungal infections such as candidiasis and mold infections cause significant morbidity and mortality in seriously ill patients.Micafungin is an echinocandin antifungal agent with potent activity against most species of Candida and Aspergillus.We did this meta-analysis to clarify whether micafungin offers superior efficacy and safety compared with other antifungal agent for treating infections associated with invasive candidiasis. Methods We did a meta-analysis of randomized controlled trials to examine whether micafungin has superior efficacy and safety compared with other antifungal agents recommended by the treatment guidelines for fungal infection.Seven trials involving 2913 patients were included in this analysis.Odds ratios(OR) and 95%confidence intervals(CI) were calculated. Results Micafungin was associated with significantly better treatment success compared with the comparator antifungal agents(modified intention to treat,2851 patients;random-effects model,OR 1.20,95%CI 1.00-1.45, P=0.0487).In addition,micafungin was more effective than the comparators for antifungal prophylaxis of neutropenic patients undergoing hematopoietic stem cell transplantation(OR 1.47,95%CI 1.08-2.00,P=0.01).Although there was no significant difference between the compared regimens in terms of the incidence of adverse drug effects(OR 0.94, 95%CI 0.77-1.11),fewer patients treated with micafungin withdrew from the studies because of adverse events(OR 0.64,95%CI 0.44-0.94). Conclusions Micafungin has a good safety and tolerability profile,with an efficacy at least comparable to the other antifungal agents.Micafungin offers advantages over other agents for antifungal prophylaxis.Micafungin offers an appropriate alternative for antifungal prophylaxis rather than the treatment of invasive Candida infections.