Antidiabetic and Anti-oxidative Effects of Honokiol on Diabetic Rats Induced by High-fat Diet and Streptozotocin

Objective To study the antidiabetic and anti-oxidative effects of honokiol(Hon)in Magnolia officinalis and its underlying molecular mechanism in diabetic rats induced by high-fat diet(HFD)and streptozotocin(STZ).Methods After ig administration with Hon[25,50,and 100 mg/(kg·d)]to diabetic rats for consecutive 10 weeks,the levels of blood glucose(BG),oral glucose tolerance(OGT),blood lipids including total cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),and low density lipoprotein-cholesterol(LDL-C),hepatic oxidative stress including the activities of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px),methane dicarboxylic aldehyde(MDA),and cytochrome P4502E1(CYP2E1)in diabetic rats were measured.Results Compared to the diabetic control rats,ig administration of Hon resulted in significant decrease in BG,TC,TG,and LDL-C levels in serum,as well as hepatic CYP2E1 activity and MDA content in diabetic rats,whereas the level of OGT and activities of hepatic CAT,SOD,and GSH-Px in diabetic rats were significantly increased.Conclusion Hon could alleviate hyperglycemia,hyperlipemia,hepatic oxidative damage,and insulin resistance in diabetic rats by inhibiting hepatic CYP2E1 activity.