Relationships between angiotensin-converting enzyme gene polymorphism and lacunar infarction in early stage of essential hypertension

被引：0

作者：

徐岩

毛建华

机构：

[1] The First Affiliated Hospital of Anhui Medical University Hefei 230022

[2] China

[3] Anhui Province

[4] Department of Angiocardiopathy

[5] The First Affiliated Hospital of Anhui Medical University

来源：

中国组织工程研究 | 2003年 / 01期

关键词：

gene expression regulation; enzymologic; brain infarction; hypertension/enzymology;

D O I：

暂无

中图分类号：

R544.1 [高血压];

学科分类号：

1002 ; 100201 ;

摘要：

AIM:To investigate the relationships between angiotensin converting enzyme gene polymorphism and lacunar infarction in patients with essential hypertension.METHODS:Polymerase chain reaction(PCR) was used to determine the genotypes for an insertion/deletion polymorphism of 287 pb fragment of ACE gene in 50 healthy persons,50 patients with simple essential hypertension and 30 patients with essential hypertension and lacunar infarction.RESULTS:There was no significant difference of genotype and allele between healthy persons and patients with simple essential hypertension;but there was significant difference of D allele and DD genotype of ACE gene between esential hypertensive patients with lacunar infarction and patients with simple essential hypertension and healthy persons.CONCLUSION:There is a significant relation between ACE gene polymorphism and essential hypertensive patients with lacunar infarction.

引用

页码：145 / 145

页数：1