The Chemical Synthesis of 4'-Thio-2'-deoxythymidine-5'-triphosphate and Its Effects on DNA Synthesis

被引：0
|
作者：
黄宝国
惠永正
吕幼仪
洪国藩
机构：
[1] Shanghai Institute of Organic Chemistry Academia Sinica Shanghai 200032 PRC
[2] Shanghai Institute of Biochemistry Academia Sinica Shanghai 200031 PRC
[3] Shanghai Institute of Organic Chemistry Academia Sinica Shanghai 200032 PRC
来源：
Science Bulletin | 1993年 / 14期
关键词：
4’-thionucleoside-5’-triphosphate; DNA replication;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Scientists have long been interested in the synthesis and medical use of 4’-thionudeosides. However, their effect on DNA synthesis has not been well studied. In order to study their bioactivity and explore new applications, we have synthesized 4’-thio-2’-deoxythymidine-5’-triphosphate (T’TP). The experimental results obtained in our lab showed that T’TP is a strong inhibitor of DNA polymerase, and the inhibition is highly specific. These prbperties indicate the potential of T’TP used for antitumor and antiviral agents as well as for the terminator in DNA sequencing.
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页码：1177 / 1180
页数：4
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