Paraoxonase activity in type 2 diabetes mellitus patients with and without complications

Objective:Type 2 diabetes mellitus(DM)is a disease of metabolic dysregulation.Current study was undertaken to know the relation between fasting lipid profile and paraoxonase 1(PON1)activity in type 2 diabetic patients with and without complications.Methods:The study group consisted of a total of 155 subjects which included non-diabetic healthy control subjects(n = 50)and diabetic patients with complications(group I,n = 66)and without complications(group II,n=39).PON1 activity was measured all the subjects based on spectrophotometric methods,and fasting lipid profile and fasting plasma glucose(FPG)levels were determined in clinical chemistry analyzer Hitachi 912.Results:FPG(P<0.001)and TAG(P<0.001)significantly increased,and HDL-C(P<0.001)and PON1(P<0.001)were significantly decreased in group I patients when compared to normal controls.In group II patients FPG(P<0.001),TAG(P<0.001)and TC(P<0.05)significantly increased and HDL-C(P<0.05)was significantly decreased when compared to normal controls.On Pearson correlation,HDL-C was positively correlated with PON1 in group I patients(r=0.317,P<0.01).Conclusion:type 2 DM patients with complications have significantly decreased HDL-C levels and PON1 activity possibly indicating its decreased biochemical role in these patients.