Effects of Electroacupuncture on Expression of COX-2 in the Dorsal Horn of Spinal Cord of Arthritic Rats

被引：0

作者：

徐红 ^{[1
]}

王彦青 ^{[2
]}

汪军 ^{[2
]}

俞瑾 ^{[2
]}

吴根诚 ^{[2
]}

朱忠春

机构：

[1] Department of Integrated Traditional and Western Medicine,Institute of Acupuncture Mechanism.Shanghai Medical College,Fudan University,Shanghai 200032,P.R.China Department of Acupuncture and Moxibustion,Longhua Hospital Affiliated to Shanghai University of

[2] Department of Integrated Traditional and Western Medicine,Institute of Acupuncture Mechanism,Shanghai Medical College,Fudan University,Shanghai 200032,P.R.China

来源：

JournalofAcupunctureandTuinaScience | 2006年 / 4卷 / 05期

关键词：

电针; 完全弗氏佐剂; 关节炎; 脊髓背角; 环氧合酶-2;

D O I：

暂无

中图分类号：

R245 [针灸学、针灸疗法];

学科分类号：

100512 ;

摘要：

目的:本工作试图通过观察慢性炎症痛大鼠脊髓背角环氧合酶(COX-2)蛋白表达的变化,探讨脊髓背角 COX-2是否与电针镇痛的作用机制有关。方法:在佐剂性关节炎大鼠的模型上,采用行为学和免疫组化技术两种方法,观察电针治疗后不同时相关节炎大鼠的痛敏评分及脊髓背角 COX-2蛋白的表达,并与正常组、模型组和药物组加以对照。结果:电针能明显减小关节炎大鼠痛敏评分的绝对值。多次电针具有显著的累积效应;并且随着电针治疗次数的增加,大鼠脊髓背角 COX-2免疫阳性细胞数显著下降。结论:电针阳陵泉和昆仑两穴对佐剂性关节炎大鼠有明显的镇痛作用,并同时抑制其脊髓背角 COX-2蛋白的表达。

引用

页码：264 / 266

页数：3

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