Real-world evidence on adjuvant chemotherapy in older adults with stage Ⅱ/Ⅲ colon cancer

被引:1
|
作者
Atul Batra [1 ]
Rodrigo Rigo [1 ]
Dropen Sheka [1 ]
Winson Y Cheung [2 ]
机构
[1] Department of Medicine, Tom Baker Cancer Centre
[2] Department of Oncology, University of Calgary
关键词
D O I
暂无
中图分类号
R735.35 [];
学科分类号
100214 ;
摘要
Colon cancer represents one of the most common cancers diagnosed in older adults worldwide. The standard of care in resected stage Ⅱ and stage Ⅲ colon cancer continues to evolve. While there is unequivocal evidence to suggest both disease free and overall survival benefits with the use of combination chemotherapy in patients with stage Ⅲ colon cancer, data regarding its use in patients with stage Ⅱ colon cancer are less clear. Further, although colon cancer is a disease that affects older adults, there is considerable debate on the value of adjuvant chemotherapy in the aging population. In particular, many older patients are undertreated when compared to their younger counterparts. In this review, we will describe the clinical trials that contributed to the current adjuvant chemotherapy approach in colon cancer, discuss representation of older adults in trials and the specific challenges associated with the management of this subpopulation, and highlight the role of comprehensive geriatric assessments. We will also review how real-world evidence complements the data gaps from clinical trials of early stage colon cancer.
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页码:604 / 618
页数:15
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