Ang-2/Ang-1及Ang-1/Tie-2与脓毒症预后研究

被引：3
|
作者：
刘禹
杨卫泽
机构：
[1] 武汉大学人民医院急诊科
来源：
华南国防医学杂志 | 2016年 / 30卷 / 11期
关键词：
血管生成素-2; 血管生成素-1; 酪氨酸激酶-2; 脓毒症; 预后;
D O I：
10.13730/j.issn.1009-2595.2016.11.006
中图分类号：
R459.7 [急症、急救处理];
学科分类号：
100218 ;
摘要：
目的通过分析血管生成素2(angiogenin-2,Ang-2)/血管生成素1(angiogenin-1,Ang-1)、Ang-1/酪氨酸激酶2(tyrosine kinase-2,Tie-2)在脓毒症中的表达,了解其在脓毒症早期诊断、危险分层、预后中的价值,并将这些因素与降钙素原(procalcitonin,PCT)在早期脓毒症中比较。方法通过酶联免疫吸附剂测定(enzyme linked immunosorbent assay,ELISA)440例诊断为脓毒症患者(观察组)及55例健康者(对照组)血液中Ang-1、Ang-2、Tie-2及PCT表达水平,比较Ang-2/Ang-1、Ang-1/Tie-2、Ang-1、Ang-2、Tie-2与PCT的预后价值。所有患者均随访28d。结果 Ang-2中位水平和Ang-2/Ang-1比值升高、Ang-1水平及Ang-1/Tie-2比值下降提示脓毒症风险程度更加严重。Ang-2/Ang-1与Ang-1/Tie-2比值在诊断及28d随访致死率受试者工作特征曲线(receiver operating characteristic curve,ROC)中面积较Ang-1、Ang-2及PCT水平大。Ang-2/Ang-1比值大于1.94的患者较Ang-2/Ang-1患者预后较差;Ang-1/Tie-2比例低于0.03者生存率较其高的要低。Ang-2/Ang-1,Ang-1/Tie-2可作为脓毒症独立预后因素。Ang-1、Ang-2与Tie-2呈正相关。在每个分组中,Ang-2/Ang-1与脓毒症患者预后呈负相关,而Ang-1/Tie-2与急诊脓毒症预后呈正相关。结论 Ang-2/Ang-1、Ang-1/Tie-2与脓毒症危险分层相关,并可预测脓毒症预后不良。
引用
收藏
页码：709 / 713
页数：5
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