Objective:To investigate the clinical significance of serum thyroid stimulating hormone（TSH） receptor antibody（TRAb） levels in pregnant women with Graves’disease,on neonatal hyperthyroidism. Methods:The clinical data of 68 pregnant women with Graves’ disease and their newborns were retrospectively analyzed.Testing indicators included thyroid function tests and TRAb levels during pregnancy,at delivery,and within 2 weeks after birth.The serum TRAb and T;,T;,Free T;,Free T;,TSH levels were detected by radio receptor assay（RRA） and electrical chemiluminescence immunoassay（ECLIA）,respectively. Results:The results showed that serum TRAb levels of the third trimester of pregnancy was positively correlated with that of the umbilical vein（n = 68,r= 0.8494,P<0.01）,and that of the newborns（n = 68, r=0.8286,P<0.01）.The incidence of neonatal hyperthyroidism was 11.8%（8/68）.The serum TRAb levels in the 8 neonates with hyperthyroidism within 2 weeks after birth were 3 times higher than those in the normal neonates.Of these 8 neonates,2 had 15 times higher serum TRAb levels than those of normal neonates within 2 weeks after birth.The thyroid function and TRAb levels of these 2 neonates were still abnormal 6 months later. Conclusions:The risk of hyperthyroidism in newborn whose mother’s TRAb levels were high in the third trimester of pregnancy was increased.This study suggests a significant correlation between TRAb levels in pregnant women with Graves’ disease and the severity of neonatal hyperthyroidism.
