NUSAP1与恶性肿瘤

被引：2

作者：

魏丽娟 ^{[1
]}

苏秀兰 ^{[2
]}

机构：

[1] 内蒙古医科大学

[2] 内蒙古医科大学附属医院临床医学研究中心

来源：

生命的化学 | 2021年 / 41卷 / 02期

关键词：

有丝分裂; 分子靶向治疗; 核仁纺锤体相关蛋白1;

D O I：

10.13488/j.smhx.20200477

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

核仁纺锤体相关蛋白1(nucleolar and spindle-associated protein 1, NUSAP1)是一种微管结合蛋白,它与微管结合后稳定微管并参与细胞分裂,与染色体结合后,促进有丝分裂纺锤体微管的形成;因此NUSAP1与细胞有丝分裂进程、纺锤体的形成有密切关系。NUSAP1的一个关键功能是在有丝分裂早期和晚期起调节作用。NUSAP1在许多恶性肿瘤中高表达,因此通过NUSAP1的靶向作用机制的研究筛选出合适的靶向药物对于恶性肿瘤的治疗具有潜在的应用前景。本文就NUSAP1在恶性肿瘤中的作用机制及其在恶性肿瘤治疗中的价值进行分析与总结。

引用

页码：289 / 295

页数：7

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