A nano-structured TiO2/CuO/Cu2O coating on Ti-Cu alloy with dual function of antibacterial ability and osteogenic activity

被引：3
|
作者：
Yuan Zhang [1 ]
Shan Fu [1 ]
Lei Yang [1 ,2 ]
Gaowu Qin [1 ,2 ]
Erlin Zhang [1 ,2 ]
机构：
[1] Key Laboratory for Anisotropy and Texture of Materials (MoE), School of Materials Science and Engineering, Northeastern University
[2] Research Center for Metallic Wires, Northeastern University
来源：
Journal of Materials Science & Technology | 2022年 / 97卷 / 02期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
TB383.1 []; TG146.23 [];
学科分类号：
070205 ; 080501 ; 080502 ; 1406 ;
摘要：
Bacteria-associated infection and poor osseointegration are two main reasons for orthopedic implant failure. Ti-Cu alloy exhibited excellent antibacterial property, but still presented unsatisfied osteogenic activities. Therefore, Ti-Cu alloy was surface modified by an alkali-heat treatment in this paper to improve the osteogenic ability without reduction in antibacterial ability. A TiO2/CuO/Cu2O composite coating with nanostructure was deposited on Ti-Cu alloy. The coating showed increased roughness and great hydrophilicity. Antibacterial tests indicated that the modified Ti-Cu alloy exhibited stronger antibacterial ability against Staphylococcus aureus(S. aureus) than Ti-Cu alloy. Meanwhile, cell experiments demonstrated that the composite coating promoted initial adhesion and spreading of MC3T3-E1 cells, enhanced alkaline phosphatase(ALP) activities as well as extracellular matrix(ECM) mineralization, and significantly upregulated osteogenesis-related gene expressions. It was suggested that the nano-structured TiO2/CuO/Cu2O coating on Ti-Cu alloy might provide a potential strategy for orthopedic implant failure.
引用
收藏
页码：201 / 212
页数：12
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