Springer-nature is announcing the call for submissions for the new open access journal Signal Transduction and Targeted Therapy. The journal will go live on www.nature.com/sigtrans.Signal Transduction and Targeted Therapy aims to publish original research articles and review articles related to all aspects of signal transduction in physiological and pathological processes, as well as signal transductiontargeted therapeutics in the form of biological agents and small molecular drugs used to treat human diseases such as cancer, autoimmune disorders, and others. The journal focuses on cutting-edge advances both experimentally and clinically.