脂滴包被蛋白Plin5参与调节脂代谢和线粒体功能

被引：6
|
作者：
罗玉珍 [1 ,2 ]
韩海军 [1 ]
陈敏 [1 ]
孙景权 [1 ]
机构：
[1] 四川大学体育学院
[2] 西南大学体育学院
来源：
生命的化学 | 2020年 / 40卷 / 08期
关键词：
运动员悖论; 脂滴包被蛋白5; 脂滴; 线粒体功能; 围脂滴线粒体;
D O I：
10.13488/j.smhx.20200110
中图分类号：
R587.1 [糖尿病];
学科分类号：
摘要：
脂滴包被蛋白5(perilipin5, Plin5)在脂肪酸氧化程度较高的组织中表达,虽然在细胞和动物模型中均发现Plin5具有促进脂滴堆积、提高线粒体功能和缓解脂毒性的作用,但Plin5如何发挥其功能特点的具体机制尚未得到分析整合。通过分析相关文献发现:Plin5可以通过和CGI-58(comparative gene identification-58)结合来调节关键脂解酶脂肪甘油三酯水解酶(adiposetiglyceridelipase, ATGL)以调控脂肪的代谢过程;通过核转位与沉默信息调节因子2相关酶1(silent mating type information regulator 2homolog 1, SIRT1)和过氧化物酶体增殖物激活受体γ辅激活因子1α(PPARγcoactivator-1α, PGC-1α)结合促进线粒体功能基因的表达,提高线粒体的氧化能力和呼吸功能;通过增加围脂滴线粒体的含量促使脂滴含量增加并增强线粒体功能,这揭示了Plin5参与调节脂代谢和线粒体功能的具体机制。而耐力运动锻炼会显著增加Plin5的含量,表明Plin5是解释"运动员悖论"现象的关键因子,这为Plin5作为新的2型糖尿病治疗靶点提供了理论依据。
引用
收藏
页码：1279 / 1288
页数：10
相关论文
共 29 条
  • [1] Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2[J] . Anne Gemmink,Sabine Daemen,Helma J.H. Kuijpers,Gert Schaart,Hans Duimel,Carmen López-Iglesias,Marc A.M.J. van Zandvoort,Kèvin Knoops,Matthijs K.C. Hesselink.BBA - Molecular and Cell Biology of Lipids . 2018
  • [2] Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion[J] . Ilan Y. Benador,Michaela Veliova,Kiana Mahdaviani,Anton Petcherski,Jakob D. Wikstrom,Essam A. Assali,Rebeca Acín-Pérez,Micha?l Shum,Marcus F. Oliveira,Saverio Cinti,Carole Sztalryd,William D. Barshop,James A. Wohlschlegel,Barbara E. Corkey,Marc Liesa,Orian S. Shirihai.Cell Metabolism . 2018 (4)
  • [3] Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?
    Gemmink, Anne
    Daemen, Sabine
    Brouwers, Bram
    Huntjens, Peter R.
    Schaart, Gert
    Moonen-Kornips, Esther
    Jorgensen, Johanna
    Hoeks, Joris
    Schrauwen, Patrick
    Hesselink, Matthijs K. C.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2018, 596 (05): : 857 - 868
  • [4] Lipid homeostasis and regulated cell death[J] . Eran Agmon,Brent R Stockwell.Current Opinion in Chemical Biology . 2017
  • [5] Higher Muscle Content of Perilipin 5 and Endothelial Lipase Protein in Trained Than Untrained Middle-Aged Men
    Vigelso, A.
    Prats, C.
    Ploug, T.
    Dela, F.
    Helge, J. W.
    [J]. PHYSIOLOGICAL RESEARCH, 2016, 65 (02) : 293 - 302
  • [6] Unraveling the roles of PLIN5: linking cell biology to physiology[J] . Rachael R. Mason,Matthew J. Watt.Trends in Endocrinology & Metabolism . 2015 (3)
  • [7] Perilipin 5 Improves Hepatic Lipotoxicity by Inhibiting Lipolysis
    Wang, Chao
    Zhao, Yuanlin
    Gao, Xing
    Li, Le
    Yuan, Yuan
    Liu, Fang
    Zhang, Lijun
    Wu, Jie
    Hu, Peizhen
    Zhang, Xiumin
    Gu, Yu
    Xu, Yuqiao
    Wang, Zhe
    Li, Zengshan
    Zhang, Huizhong
    Ye, Jing
    [J]. HEPATOLOGY, 2015, 61 (03) : 870 - 882
  • [8] ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1[alpha]/PPAR-[alpha] Signaling[J] . Khan,SaImaan Ahmed,Sathyanarayan,Aishwarya,Mashek,Mara T,Ong,Kuok Teong,Wollaston-Hayden,Edith E,Mashek,Douglas G.Diabetes . 2015 (2)
  • [9] Thyromimetic actions of tetrabromobisphenol A (TBBPA) in steatotic FaO rat hepatoma cells[J] . E. Grasselli,K. Cortese,R. Fabbri,A. Smerilli,L. Vergani,A. Voci,G. Gallo,L. Canesi.Chemosphere . 2014
  • [10] PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle
    Mason, Rachael R.
    Mokhtar, Ruzaidi
    Matzaris, Maria
    Selathurai, Ahrathy
    Kowalski, Greg M.
    Mokbel, Nancy
    Meikle, Peter J.
    Bruce, Clinton R.
    Watt, Matthew J.
    [J]. MOLECULAR METABOLISM, 2014, 3 (06): : 652 - 663
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