Colorectal cancer;
Cancer screening;
Feces;
Occult blood;
Risk factors;
Predictive value of tests;
D O I:
暂无
中图分类号:
R735.3 [肠肿瘤];
学科分类号:
100214 ;
摘要:
AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in China.METHODS:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) and other high risk factors questionnaire in a population sample of 13 214 community residents who completed both the iFOBT and questionnaire investigation.Patients with either a positive iFOBT and/or questionnaire were regarded as a high risk population and those eligible were asked to undergo colonoscopy.RESULTS:The iFOBT had the highest positive predictive value and negative predictive value in screening for advanced neoplasia.The iFOBT had the highest sensitivity,lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.A history of chronic cholecystitis or cholecystectomy,chronic appendicitis or appendectomy,and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and adenomas.The sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for nonadenomatous polyps.A history of chronic appendicitis or appendectomy,chronic constipation,chronic diarrhea,mucous and bloody stool,CRC in first degree relatives,malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous polyps.Except for a history of malignant tumor in screening for non-adenomatous polyps,the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra abnormality.CONCLUSION:The iFOBT may be the best marker for screening for advanced neoplasias and adenomas.Some unique high risk factors may play an important role in CRC screening in China.
机构:
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center of Gastrointestinal Surgery, Peking University Cancer Hospital & InstituteKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
机构:
Zhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Xu, Hui-Fang
Gu, Xiao-Fen
论文数: 0引用数: 0
h-index: 0
机构:
Xinjiang Med Univ, Affiliated Tumor Hosp, Dept Student Affairs, Urumqi, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Gu, Xiao-Fen
Wang, Xiao-Hui
论文数: 0引用数: 0
h-index: 0
机构:
Gansu Prov Canc Hosp, Dept Publ Hlth, Lanzhou, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Wang, Xiao-Hui
Wang, Wen-Jun
论文数: 0引用数: 0
h-index: 0
机构:
Jining Med Univ, Sch Nursing, Jining, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Wang, Wen-Jun
Du, Ling-Bin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Canc Prevent, Hangzhou, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Du, Ling-Bin
Duan, Shuang-Xia
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Cent Hosp, Dept Prevent Hlth, Xinxiang, Henan, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Duan, Shuang-Xia
Liu, Yin
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Liu, Yin
Zhang, Xi
论文数: 0引用数: 0
h-index: 0
机构:
Peking Univ, Canc Hosp & Inst, Beijing Off Canc Prevent & Control, Minist Educ Beijing,Key Lab Carcinogenesis & Tran, Beijing, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Zhang, Xi
Zhao, Yu-Qian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Ctr Canc Prevent Res, Sichuan Canc Ctr,Sch Med, Chengdu, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Zhao, Yu-Qian
Ma, Li
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Publ Hlth Sch, Dalian, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Ma, Li
Liu, Yun-Yong
论文数: 0引用数: 0
h-index: 0
机构:
Canc Hosp China Med Univ, Liaoning Canc Hosp & Inst, Liaoning Off Canc Control & Res, Shenyang, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Liu, Yun-Yong
Huang, Juan-Xiu
论文数: 0引用数: 0
h-index: 0
机构:
Wuzhou Red Cross Hosp, Dept Gastroenterol, Wuzhou, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Huang, Juan-Xiu
Cao, Ji
论文数: 0引用数: 0
h-index: 0
机构:
Guangxi Med Univ, Affiliated Hosp 1, Dept Canc Prevent & Control Off, Nanning, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Cao, Ji
Fan, Yan-Ping
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Fan, Yan-Ping
论文数: 引用数:
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机构:
Li, Li
Feng, Chang-Yan
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Univ, Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis &, Chongqing, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Feng, Chang-Yan
Lian, Xue-Mei
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Lian, Xue-Mei
Du, Jing-Chang
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Du, Jing-Chang
Zhang, Jian-Gong
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Zhang, Jian-Gong
Yu, Yan-Qin
论文数: 0引用数: 0
h-index: 0
机构:
Baotou Med Coll, Clin Epidemiol Res Ctr, Dept Publ Hlth & Prevent Med, Baotou 014010, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Yu, Yan-Qin
Qiao, You-Lin
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Ctr Global Hlth, Sch Populat Med & Publ Hlth, Beijing 100005, Peoples R ChinaZhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control,Affilia, Dept Canc Epidemiol,Henan Int Joint Lab Canc Prev, Zhengzhou 450008, Peoples R China