Expression of leptin and leptin receptor in gastric carcinoma

被引：0
|
作者：
王颖
机构：
[1] Dept Internal Med
[2] Wuhan 430060
[3] Renmin Hosp Wuhan Univ
来源：
外科研究与新技术 | 2005年 / 03期
关键词：
D O I：
暂无
中图分类号：
R735.2 [胃肿瘤];
学科分类号：
100214 ;
摘要：
To determine the expression of leptin and leptin receptor in gastric carcinoma and investigate their role in carciagenesis and development of gastric carcinoma.Methods The expression of leptin and leptin receptor protein was detected in 54 cases of gastric carcinoma tissues by immunohistochemistry.The correlatin between their expression and clinicallpathological parameters was also analysized.Results The expression rate of leptin and leptin receptor in gastric carcinoma was 72.22%(39/54) and 74.07%(40/54) respectively.The expression rate of leptin in intestinal-type gastric cancer was significantly higher than in diffuse-type gastric cancer.The expression rate of leptin was associated with differentiation,tumor size,metastasis,and TNM stage.Conclusion Leptin and leptin receptor were dually expressed in gastric carcinoma.They participate in the early stage of malignant transformation and have certain role in the advanced stage.3 refs,1 tab.
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页码：164 / 164
页数：1
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