基于UPLC-Q-Exactive Orbitrap-MS的栀子柏皮汤化学成分分析

被引：0

作者：

景涵 ^{[1
]}

冯芳 ^{[1
,2
]}

机构：

[1] 中国药科大学药物分析教研室

[2] 药物质量与安全预警教育部重点实验室

来源：

广州化工 | 2022年 / 50卷 / 16期

关键词：

栀子柏皮汤; 成分分析; 超高效液相色谱-四级杆-静电场轨道阱质谱;

D O I：

暂无

中图分类号：

O657.63 [质谱分析]; R286.0 [药品鉴定];

学科分类号：

摘要：

运用超高效液相色谱-四级杆-静电场轨道阱质谱（UPLC-Q-Exactive Orbitrap-MS）技术对栀子柏皮汤化学成分进行了快速、全面分析。采用XBridge BEH C18色谱柱（2.1 mm×100 mm, 2.5μm）,以0.1%甲酸水-乙腈为流动相进行梯度洗脱，流速0.3 mL/min,进样量3μL;运用加热电喷雾电离源（HESI）在正、负离子模式下采集数据。通过比对质谱数据和对照品保留时间等，共鉴定出栀子柏皮汤中的146个化学成分，为后续的质量控制和作用机制研究奠定了基础。

引用

页码：81 / 87

页数：7

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