Cross-coupling of 2-methylquinolines and in-situ activated isoquinolines: Construction of 1,2-disubstituted isoquinolinones

被引：0

作者：

Jianyi Shi ^{[1
]}

Zheng Zeng ^{[2
]}

Shengting Xu ^{[1
]}

Zechun Cai ^{[1
]}

Yuehua Luo ^{[1
]}

Yongbo Fan ^{[1
]}

Zhongzhi Zhu ^{[1
]}

Tingting Wen ^{[1
]}

Xiuwen Chen ^{[1
]}

机构：

[1] School of Biotechnology and Health Sciences, Wuyi University

[2] Affiliated Hospital of Guilin Medical University

来源：

Chinese Chemical Letters | 2022年 / 33卷 / 11期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

O626.323 [];

学科分类号：

070303 ; 081704 ;

摘要：

In this study,a method was developed to form C(sp~3)-C(sp~2) bonds via copper catalyst-promoted cross coupling of 2-methylquinoline and in-situ-activated 3-haloisoquinoline under mild conditions.The multicomponent tandem reaction was used to construct new C-N,C=O and C-C bonds in one pot via sequential functionalization of the N1,C3 and C1 positions of 3-haloisoquinoline.This method can be used to efficiently access 1,2-disubstituted isoquinolinones by the three-component reaction of 3-halogen isoquinoline,alkyl halide,and 2-methylquinoline.

引用

页码：4874 / 4877

页数：4

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