MicroRNA-200家族在中枢神经系统中的作用及其研究进展

被引：4
|
作者：
胡小彤
张兵
机构：
[1] 哈尔滨医科大学附属第二医院黑龙江省麻醉与危重病学重点实验室
来源：
卒中与神经疾病 | 2018年 / 25卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R741 [神经病学];
学科分类号：
摘要：
<正>MicroRNA是一类内生的、长度为20～24个核苷酸的小RNA。脊椎动物中miRNA-200家族包括miR-200a、miR-200b、miR-200c、miR-141和miR-429五种,它们作用于下游的mRNA,调控相关蛋白的合成与降解,从而调节各种信号通路来影响相关生理及病理过程,在中枢神经系统中发挥重要作用。明确各种miRNA-200家族在机体中的作用及其机
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页码：218 / 220
页数：3
相关论文
共 14 条
  • [1] MicroRNA abundance is altered in synaptoneurosomes during prion disease.[J].Amrit S. Boese;Reuben Saba;Kristyn Campbell;Anna Majer;Sarah Medina;Lynn Burton;Timothy F. Booth;Patrick Chong;Garrett Westmacott;Sucharita M. Dutta;Julian A. Saba;Stephanie A. Booth.Molecular and Cellular Neuroscience.2016,
  • [2] Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells
    Santra, Manoranjan
    Chopp, Michael
    Santra, Sutapa
    Nallani, Ankita
    Vyas, Shivam
    Zhang, Zheng Gang
    Morris, Daniel C.
    [J]. JOURNAL OF NEUROCHEMISTRY, 2016, 136 (01) : 118 - 132
  • [3] Critical role of the miR-200 family in regulating differentiation and proliferation of neurons
    Pandey, Ankita
    Singh, Parul
    Jauhari, Abhishek
    Singh, Tanisha
    Khan, Farah
    Pant, Aditya B.
    Parmar, Devendra
    Yadav, Sanjay
    [J]. JOURNAL OF NEUROCHEMISTRY, 2015, 133 (05) : 640 - 652
  • [4] MicroRNA-200c Contributes to Injury From Transient Focal Cerebral Ischemia by Targeting Reelin
    Stary, Creed M.
    Xu, Lijun
    Sun, Xiaoyun
    Ouyang, Yi-Bing
    White, Robin E.
    Leong, Jason
    Li, John
    Xiong, Xiaoxing
    Giffard, Rona G.
    [J]. STROKE, 2015, 46 (02) : 551 - U356
  • [5] microRNA-200b modulates microglia-mediated neuroinflammation via the cJun/MAPK pathway
    Jadhav, Shweta P.
    Kamath, Sandhya P.
    Choolani, Mahesh
    Lu, Jia
    Dheen, S. Thameem
    [J]. JOURNAL OF NEUROCHEMISTRY, 2014, 130 (03) : 388 - 401
  • [6] MicroRNAs Expression and Function in Cerebral Ischemia Reperfusion Injury
    Yu Di
    Yang Lei
    Feng Yu
    Fan Changfeng
    Wang Song
    Mo Xuming
    [J]. JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 53 (02) : 242 - 250
  • [7] MiR-200a impairs glioma cell growth, migration, and invasion by targeting SIM2-s
    Su, Yuhang
    He, Qiaowei
    Deng, Lin
    Wang, Juntao
    Liu, Qinglin
    Wang, Donghai
    Huang, Qibing
    Li, Gang
    [J]. NEUROREPORT, 2014, 25 (01) : 12 - 17
  • [8] MiR-200, a new star miRNA in human cancer
    Feng, Xiangling
    Wang, Zhengming
    Fillmore, Rebecca
    Xi, Yaguang
    [J]. CANCER LETTERS, 2014, 344 (02) : 166 - 173
  • [9] MicroRNA-200b targets CREB1 and suppresses cell growth in human malignant glioma.[J].Biao Peng;Su Hu;Qinming Jun;Dongdong Luo;Xun Zhang;Hailin Zhao;Dan Li.Molecular and Cellular Biochemistry.2013, 1
  • [10] Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin
    Jin, Jing
    Cheng, Yong
    Zhang, Yongqing
    Wood, William
    Peng, Qi
    Hutchison, Emmette
    Mattson, Mark P.
    Becker, Kevin G.
    Duan, Wenzhen
    [J]. JOURNAL OF NEUROCHEMISTRY, 2012, 123 (04) : 477 - 490
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