Treatment and five-year follow-up of type A insulin resistance syndrome: A case report

被引：0
|
作者：
Yong-Hua Chen [1 ]
Qing-Qing Chen [1 ]
Chun-Lin Wang [1 ]
机构：
[1] Department of Pediatrics, the First Affiliated Hospital, Zhejiang University School of Medicine
来源：
World Journal of Clinical Cases | 2022年 / 08期
关键词：
D O I：
暂无
中图分类号：
R587 [胰岛疾病];
学科分类号：
1002 ; 100201 ;
摘要：
BACKGROUND Type A insulin resistance syndrome(TAIRS) is a rare disorder characterized by severe insulin resistance due to defects in insulin receptor signaling. No specific drugs are available for the treatment of TAIRS. We report a case of TAIRS successfully treated with pioglitazone and flutamide for 5 years.CASE SUMMARY We present the rare case of a female patient aged 11 years and 9 mo with type A insulin resistance and an INSR heterozygous mutation(c.3614 C>T), who was treated with a combination of pioglitazone and flutamide. This treatment regimen reduced hemoglobin A1 c, fasting insulin and androgen levels.CONCLUSION Pioglitazone attenuated insulin resistance in this patient with TAIRS, and flutamide ameliorated masculinization.
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页码：2522 / 2528
页数：7
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