乳腺癌组织中lncRNA CCHE1水平及其临床意义

被引：10
|
作者：
熊晶 [1 ]
王渝 [1 ]
王君 [1 ]
周晟 [1 ]
机构：
[1] 华中科技大学同济医学院附属同济医院病理研究所
来源：
临床肿瘤学杂志 | 2018年 / 23卷 / 06期
关键词：
乳腺癌; 长链非编码RNA; CCHE1; 预后;
D O I：
暂无
中图分类号：
R737.9 [乳腺肿瘤];
学科分类号：
100214 ;
摘要：
目的探讨长链非编码RNA(lncRNA)CCHE1在乳腺癌组织中的表达及其临床意义。方法收集本院2011年1月至2012年12月切除的乳腺癌组织115例和配对癌旁组织78例,采用实时荧光定量PCR(QPCR)检测CCHE1在上述组织中的表达情况,比较乳腺癌组织和癌旁组织中的CCHE1水平;分析CCHE1水平与乳腺癌临床病理参数(年龄、临床T分期、组织学分级、淋巴结转移、Nottingham预后指数、Ki-67增殖指数、ER表达、PR表达及HER-2扩增)和复发的关系;分析不同CCHE1水平的总生存期(OS)和无进展生存期(PFS),采用Cox比例风险模型进行多因素分析。结果 QPCR检测发现,115例乳腺癌组织中的CCHE1水平为7.610±3.210,高于癌旁组织的2.142±1.753(P<0.05)。CCHE1水平与临床T分期、淋巴结转移、Nottingham预后指数、HER-2扩增和肿瘤复发有关(P<0.05),而与年龄、组织学分级、ER表达、PR表达和Ki-67增殖指数无关(P>0.05)。CCHE1低表达组的中位PFS和OS分别为56.0个月和63.0个月,均优于高表达组的37.0个月和42.0个月(P<0.05);CCHE1水平、临床T分期、淋巴结转移、Nottingham预后指数和HER-2扩增是影响OS和PFS的独立预后因素(P<0.05)。结论 CCHE1在乳腺癌组织中表达升高,该lncRNA可能在乳腺癌的发生、发展中有一定作用,可作为潜在地评估乳腺癌患者预后的分子标志物。
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页码：519 / 523
页数：5
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