IFN-γ、IL-4、TGF-β在诱导EAMG耐受中的作用

被引：1

作者：

梁丽云 ^{[1
]}

马存根 ^{[1
]}

丰玲 ^{[1
]}

机构：

[1] 大同医学专科学校中心实验室!山西大同037008

来源：

免疫学杂志 | 2000年 / 04期

关键词：

实验性自身免疫性重症肌无力; 耐受; IFN-γ; IL-4; TGF-β;

D O I：

10.13431/j.cnki.immunol.j.20000086

中图分类号：

R746.1 [重症肌无力];

学科分类号：

1002 ;

摘要：

目的为探讨鼻腔耐受和 Wistar大鼠对 EAMG耐受的机制。方法用放射标记的 c DNA寡核苷酸作探针原位杂交计数免疫后第 7周表达 IFN-γ、IL - 4和 TGF-β m RNA的 MNC。结果 EAMG大鼠 PIL N和脾脏中 IFN-γ m RNA表达细胞数比 CFA大鼠高 (P<0 .0 5 ) ;鼻腔耐受大鼠 PIL N中 IFN-γ和 IL - 4m RNA表达细胞数比 EAMG大鼠低 ,PIL N、脾脏和胸腺中 TGF-β m RNA表达细胞数比 EAMG大鼠高 (P<0 .0 5 ) ;WF大鼠 PIL N中 IFN-γ m RNA表达细胞数比 EAMG大鼠低 ,TGF- β m RNA表达细胞数比 EAMG大鼠高 (P<0 .0 5 )。结论 IFΝ- γ表达增高与 EAMG发生有关 ,IFN- γ表达降低 TGF- β表达增高与 EAMG耐受有关 ;TGF- β表达增高在 EAMG耐受中起重要作用。

引用

页码：275 / 277

页数：3

共 7 条

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