Synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by a-chymotrypsin

被引：2

作者：

Shi-Guo Zhang ^{[1
]}

Zong-Bo Xie ^{[2
,1
]}

Lian-Sheng Liu ^{[1
]}

Meng Liang ^{[1
]}

Zhang-Gao Le ^{[2
,1
]}

机构：

[1] School of Chemistry, Biology and Material Science, East China University of Technology

[2] Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology

来源：

ChineseChemicalLetters | 2017年 / 28卷 / 01期

基金：

中国国家自然科学基金;

关键词：

2,3-Dihydroquinazolin-4(1H)-ones; a-Chymotrypsin; Cyclocondensation; Biocatalysis; 2-Aminobenzamides;

D O I：

暂无

中图分类号：

O643.3 [催化]; O626 [杂环化合物];

学科分类号：

070303 ; 081704 ; 081705 ;

摘要：

We discovered that a-chymotrypsin has a promiscuous ability to catalyze the cyclocondensation of aromatic and aliphatic aldehydes with 2-aminobenzamides to afford the corresponding 2,3-dihydroquinazolin-4(1H)-ones successfully in high yields(90%–98%) under alcohol solvent. The catalytic activity of a-chymotrypsin was evaluated through investigating the temperature, the enzyme loading and the ratio of substrates in the enzyme-catalyzed reactions. The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield, green catalyst and the clean products obtained without further purification processes.

引用

页码：101 / 104

页数：4

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