Effects of aqueous extract of Notobasis syriaca on lipopolysaccharide-induced inflammation in rats

Objective: To investigate the effects of a dry aqueous extract of Notobasis syriaca(N. syriaca)on lipopolysaccharide(LPS)-induced inflammation in rats. Methods: Rats were fed the dried extract [500 mg/(kg·d)] for three consecutive days and then were intraperitoneally injected with LPS(1 mg/kg). Two hours after LPS injection, rats were sacrificed and blood and brain regions were collected. Inflammatory mediators’ levels in plasma and homogenates of brain regions were determined by ELISA. Results: Pretreatment with the N. syriaca extract resulted in significant anti-inflammatory effects(P<0.05), including: i) attenuated LPS-induced hypothermia; ii) decreased hypothalamus and hippocampus prostaglandin E2levels in the LPStreated rats; and, iii) reduced hypothalamus and hippocampus interleukin-6 and tumor necrosis factor-a levels in the LPS-treated rats. Conclusions: These results suggest that N. syriaca possesses anti-inflammatory properties. Thus, it is possible that long-term consumption of this plant may result in beneficial pharmacological effects.