BACKGROUND AND OBJECTIVE The U.S.Food and Drug Administration has approved Low Intensity Pulsed Ultrasound(LIPUS)to accelerate fracture healing.This systematic review further assessed the efficacy of LIPUS for radiographic healing and clinical efficacy.METHODS Medical databases were searched for controlled studies concerning the efficacy of LIPUS for the healing of fiactures,published through November of 2016.The outcomes included time to return to work,full weight bearing,pain reduction,bone healing and subse-