痛风性炎症自发性缓解的分子机制概述

被引：12

作者：

陈玉年 ^{[1
]}

顾兵 ^{[1
]}

李华南 ^{[2
]}

余兆仲 ^{[2
]}

机构：

[1] 江西科技师范大学药学院

[2] 江西中医药大学附属医院骨伤三科

来源：

中国药理学通报 | 2019年 / 10期

关键词：

痛风; 炎症反应; 自发性缓解; 分子机制; NLRP3炎症小体; 内源性白细胞介素1受体拮抗剂; 中性粒细胞胞外诱捕网;

D O I：

暂无

中图分类号：

R589.7 [嘌呤（Purine）代谢障碍];

学科分类号：

摘要：

急性痛风发作后会在一定时间内自行消退,这一过程称之为痛风性炎症的自发性缓解。其病理生理学机制与机体免疫系统中多种组分的动态调节有关,包括通过自身免疫细胞的吞噬,NLRP3炎症小体、白细胞介素1(interleukin 1,IL-1)和Toll样受体(Toll-like receptors,TLRs)等炎性介质的负调控,中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)在晶体沉积部位的募集,以及局部慢性肉芽肿的形成等。该文就痛风性炎症自发性缓解的分子机制作一概述。

引用

页码：1353 / 1356

页数：4

共 13 条

[1] 治疗自身免疫病药物研究进展
张玲玲
魏伟
[J]. 中国药理学通报, 2019, (02) : 149 - 156
[2] TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses
Luo, Lin
Wall, Adam A.
Tong, Samuel J.
Hung, Yu
Xiao, Zhijian
Tarique, Abdullah A.
Sly, Peter D.
Fantino, Emmanuelle
Marzolo, Maria-Paz
Stow, Jennifer L.
[J]. CELL REPORTS, 2018, 24 (11): : 3033 - 3044
[3] COPs and POPs Patrol Inflammasome Activation
Indramohan, Mohanalaxmi
Stehlik, Christian
Dorfleutner, Andrea
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2018, 430 (02) : 153 - 173
[4] Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
Jiang, Hua
He, Hongbin
Chen, Yun
Huang, Wei
Cheng, Jinbo
Ye, Jin
Wang, Aoli
Tao, Jinhui
Wang, Chao
Liu, Qingsong
Jin, Tengchuan
Jiang, Wei
Deng, Xianming
Zhou, Rongbin
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (11): : 3219 - 3238
[5] A new lead to NLRP3 inhibition
Lamkanfi, Mohamed
Dixit, Vishva M.
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (11): : 3147 - 3149
[6] Gout: An old disease in new perspective – A review[J] . Gaafar Ragab,Mohsen Elshahaly,Thomas Bardin.Journal of Advanced Research . 2017 (5)
[7] Molecular Pathophysiology of Gout
Desai, Jyaysi
Steiger, Stefanie
Anders, Hans-Joachim
[J]. TRENDS IN MOLECULAR MEDICINE, 2017, 23 (08) : 756 - 768
[8] SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions[J] . Emil Carlsson,Jeak Ling Ding,Bernadette Byrne.BBA - Molecular Cell Research . 2015
[9] Study for Updated Gout Classification Criteria: Identification of Features to Classify Gout[J] . William J. Taylor,Jaap Fransen,Tim L. Jansen,Nicola Dalbeth,H. Ralph Schumacher,Melanie Brown,Worawit Louthrenoo,Janitzia Vazquez‐Mellado,Maxim Eliseev,Geraldine McCarthy,Lisa K. Stamp,Fernando Perez‐Ruiz,Francisca Sivera,Hang‐Korng Ea,Martijn Gerritsen,Carlo Scire,Lorenzo Cavagna,Chingtsai Lin,Yin‐Yi Chou,Anne Kathrin Tausche,Ana Beatriz Vargas‐Santos,Matthijs Janssen,Jiunn‐Horng Chen,Ole Slot,Marco
[10] Anakinra for the treatment of acute severe gout in critically ill patients
Thueringer, Jessica T.
Doll, Natalie K.
Gertner, Elie
[J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 2015, 45 (01) : 81 - 85

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