内侧隔核注射Aβ25-35抑制大鼠海马CA1区theta节律

被引：1

作者：

杨东 ^{[1
]}

沈煜泰 ^{[2
]}

王晓晖 ^{[1
]}

李少凤 ^{[1
]}

张俊芳 ^{[1
]}

祁金顺 ^{[1
]}

机构：

[1] 山西医科大学生理学系

[2] 北京师范大学认知神经科学与学习国家重点实验室

来源：

神经解剖学杂志 | 2011年 / 27卷 / 04期

基金：

高等学校博士学科点专项科研基金;

关键词：

内侧隔核; 淀粉样蛋白; 海马; theta节律; 长时程增强;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

目的:研究内侧隔核(MS)注射淀粉样蛋白25-35片段(Aβ25-35)对大鼠海马CA1区theta节律和长时程增强(LTP)的影响。方法:选用成年雄性SD大鼠,在其MS分别注射Aβ25-35和生理盐水,经一周恢复后,乌拉坦麻醉状态下进行海马CA1区theta节律和场兴奋性突触后电位的在体记录。结果:MS注射Aβ25-35后,经夹尾诱发的大鼠海马CA1区theta节律(3-4 Hz)的功率(22.7±1.84 dB)明显较对照组(30.6±1.91 dB)降低(P<0.01),但与对照组相比Aβ25-35不影响海马CA1区基础性突触传递和高频刺激诱发的LTP(P>0.05)。结论:MS注射Aβ25-35可显著抑制海马CA1区theta节律,提示这可能会影响动物的探索行为,但Aβ对MS造成的伤害尚不足以改变海马CA1区的突触可塑性。

引用

页码：389 / 394

页数：6

共 8 条

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