干细胞定向分化胰岛β细胞新进展

被引：3

作者：

沈益行

曾凡一

机构：

[1] 上海交通大学医学院医学科学院发育生物学研究室

来源：

中国生物工程杂志 | 2011年 / 31卷 / 01期

关键词：

干细胞; 定向分化; 胰岛β细胞; 胰十二指肠同源异型盒基因(Pdx1); 胰高血糖素样肽-1(GLP1);

D O I：

10.13523/j.cb.20110114

中图分类号：

R587.1 [糖尿病];

学科分类号：

摘要：

在治疗糖尿病领域里,干细胞定向分化成胰岛β细胞是目前新颖又有前景的一种糖尿病治疗策略,不仅克服了注射胰岛素所带来的并发症,还避免了胰岛移植供体来源的短缺不足。目前供体细胞的材料主要有从胰腺中分离出的胰腺干细胞/胰腺祖细胞、胰腺导管细胞、胰腺泡细胞、肝实质细胞、小肠细胞、神经干细胞、ES细胞以及近来研究热点之一的iPS细胞。以上这些细胞都被证明或多或少具备分化成胰岛素分泌的细胞形态的潜力。在体外分化技术方面,国际上有D’Amour法、Lumelsky法等。现对干细胞定向分化胰岛β细胞的一些研究概况作简单评述。

引用

页码：70 / 74

页数：5

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