Prospective,randomized,controlled study of in vitro fertilization-embryo transfer with single-dose and multiple-dose GnRH antagonist (cetrorelix) or a short protocol of the GnRH agonist (triptorelin) in Chinese women

被引:0
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作者
腊晓琳 [1 ,2 ]
马彩虹 [1 ]
刘平 [1 ]
陈贵安 [1 ]
乔杰 [1 ]
机构
[1] Center for Reproductive Medicine,Peking University Third Hospital
[2] Center for Reproductive Medicine,First Affiliated Hospital of Xinjiang Medicial University
关键词
In vitro fertilization-embryo transfer; GnRH antagonist; Cetrorelix;
D O I
暂无
中图分类号
R714.8 [];
学科分类号
100211 ;
摘要
Objective:To confirm the value of GnRH antagonist(GnRHant) cetrorelix in preventing the occurrence of premature LH surges and compare a multiple dose and a single dose GnRHant protocols for the COS of IVF/ICSI patients with a short GnRHa protocol. Methods:Single-center randomized,prospective,controlled study was conducted in our study.Ninety infertile women who underwent ovarian stimulation for IVF-ET were selected.Multiple dose of 0.25 mg(Group I) and single dose of 3 mg(GroupⅡ)of cetrorelix(60 patients) was administered in the late follicular phase.A depot preparation of triptorelin(Decapeptyl) was chosen as a control agent(30 patients)(GroupⅢ).Ovarian stimulation was conducted with FSH. Results:No premature LH surge occurred after cetrorelix administration.The mean numbers of mature oocytes obtained from patients were(13.47 7.60),(18.66 8.37) and(15.77 10.78) in GroupsⅠ,ⅡandⅢ,respectively, showing no statistical difference.The fertilization rates were(78.97 18.11)%in GroupⅠ,(72.35 25.44)%in GroupⅡand(76.80 23.10)%in GroupⅢ.The clinical pregnancy rates of patients were statistically comparable in the GnRHa group(30.8%) and in the GnRHant group(37.9%in GroupⅠ,28.6%in GroupⅡ),as ongoing pregnancy rates of embryo transfer were 31.0%,25.9%,30.8%for the GroupⅠ,ⅡandⅢ,respectively.The miscarriage rate was not different in the three groups.There were four patients cancelled embryo transfer for preventing severe ovarian hyperstimulation syndrome(OHSS) in triptorelin group,and 1 patient in each cetrorelix group.No severe or moderate OHSS of cetrorelix groups occurred. Conclusion:Both single-dose and multi-dose cetrorelix protocols prevented premature LH surges in all patients studied.GnRHant and GnRHa provide comparable results in patients,while GnRHant allows a higher flexibility in the treatment.
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页码:15 / 19
页数:5
相关论文
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  • [1] Comparison of GnRH agonists and antagonists in unselected IVF/ICSI patients treated with different controlled ovarian hyperstimulation protocols: a matched study[J] . Juan C.Barros Del Gadillo,Ernst Siebzehnrübl,Ralf Dittrich,Ludwig Wildt,Norbert Lang.European Journal of Obstetrics and Gynecology . 2002 (2)
  • [2] Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin)[J] . Fertility and Sterility . 2000 (2)