microRNA-106b-5p在胃癌中的表达及与病理分级和预后的相关性研究

被引：0

作者：

辛瑞娟 ^{[1
]}

李智勇 ^{[2
]}

曹贞子 ^{[1
]}

姚丽 ^{[1
]}

游颜杰 ^{[1
]}

白飞虎 ^{[1
]}

机构：

[1] 宁夏回族自治区人民医院消化内科

[2] 宁夏回族自治区人民医院胃肠外科

来源：

宁夏医学杂志 | 2021年 / 43卷 / 05期

关键词：

胃癌; 病理分级; 预后;

D O I：

10.13621/j.1001-5949.2021.05.0411

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

摘要：

目的研究microRNA-106b-5p(miR-106b)在胃癌组织中的表达水平及与胃癌患者临床病理资料和预后之间的关系。方法分析收治的25例胃癌患者临床资料,记录患者病理分级资料,通过qRT-PCR验证miR-106b在胃癌组织中的相对表达量,分析其与患者性别、年龄、分化程度、淋巴结转移、TNM分期之间的关系。结果在25对胃癌及癌旁组织中,miR-106b的相对表达量分别为(0.9259,1.4216)、(0.2155,0.3568),胃癌组织中miR-106b的表达水平显著高于癌旁组织(P<0.05);miR-106b的表达水平与胃癌患者淋巴结转移、TNM分期有关(P<0.05);生存分析显示miR-106b高表达组整体生存时间与低表达组生存时间比较差异无统计学意义(P>0.05)。结论 miR-106b在胃癌组织中表达呈较高水平,对胃癌的病情评估有指导意义。

引用

页码：411 / 413

页数：3

共 16 条

[1] Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer[J]. Gen Tamura. World Journal of Gastroenterology. 2006(02)
[2] miR-106b-25/miR-17-92 clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma
Weiqi Tan
Yang Li
Seng-Gee Lim
Theresa MC Tan
[J]. World Journal of Gastroenterology, 2014, 20 (20) : 5962 - 5972
[3] WS 316-2010. 胃癌诊断标准[S]. 2010
[4] Dysregulated microRNA expression profiles in gastric cancer cells with high peritoneal metastatic potential
Feng, Yaning
Bai, Feihu
You, Yanjie
Bai, Fangyun
Wu, Chuanxia
Xin, Ruijuan
Li, Xue
Nie, Yongzhan
[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 16 (06) : 4602 - 4608
[5] MiR-106b regulates the apoptosis and tumorigenesis of hepatocellular carcinoma via targeting Zinc finger and BTB domain-containing protein 7A (Zbtb7a)
Liang, Xiao
Zhao, Qinghua
Geng, Tingting
Luo, Shengshu
He, Qin
[J]. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2018, 32 (08)
[6] Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts[J] . Yuki Tatekoshi,Masaya Tanno,Hidemichi Kouzu,Koki Abe,Takayuki Miki,Atsushi Kuno,Toshiyuki Yano,Satoko Ishikawa,Wataru Ohwada,Tatsuya Sato,Takeshi Niinuma,Hiromu Suzuki,Tetsuji Miura. ournal of Molecular and Cellular Cardiology . 2018
[7] miR-106b promotes cell invasion and metastasis via PTEN mediated EMT in ESCC
Zhang, Jianxiang
Chen, Danjie
Liang, Shuying
Wang, Jun
Liu, Can
Nie, Caiping
Shan, Zhengzheng
Wang, Liuxing
Fan, Qinxia
Wang, Feng
[J]. ONCOLOGY LETTERS, 2018, 15 (04) : 4619 - 4626
[8] MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN[J] . Ting-Song Yang,Xiao-Hu Yang,Xi Chen,Xu-Dong Wang,Jie Hua,Dong-Lei Zhou,Bo Zhou,Zhen-Shun Song. EBS Letters . 2014
[9] Down-regulation of miR-106b suppresses the growth of human glioma cells
Zhang, Anling
Hao, Jianwei
Wang, Kun
Huang, Qiang
Yu, Kai
Kang, Chunsheng
Wang, Guangxiu
Jia, Zhifan
Han, Lei
Pu, Peiyu
[J]. JOURNAL OF NEURO-ONCOLOGY, 2013, 112 (02) : 179 - 189
[10] miRNAs as molecular biomarkers of cancer
Fabbri, Muller
[J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2010, 10 (04) : 435 - 444

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