LOW MOLECULAR WEIGHT HEPARIN DECREASES THE ALBUMINURIA AND RENAL PATHOLOGICAL CHANGES IN DIABETIC NEPHROPATHY RATS

被引：0
|
作者：
王锋 [1 ]
邢涛 [2 ]
汪年松 [1 ]
晏春根 [3 ]
机构：
[1] Department of Nephrology,the Sixth People's Hospital,Shanghai Jiaotong University
[2] Australian School of Advanced Medicine,Macquarie University
[3] Department of Internal Medicine,Hospital Affiliated to Medical College,Shaoxing College of Arts and Science
来源：
Medical Bulletin of Shanghai Jiaotong University | 2010年 / 22卷 / 02期
关键词：
diabetic nephropathy heparin P-selectin;
D O I：
暂无
中图分类号：
R587.2 [糖尿病性昏迷及其他并发症];
学科分类号：
1002 ; 100201 ;
摘要：
Objective To investigate the renoprotection effect of low molecular weight heparin(LMWH)in diabetic rats.Methods Diabetic rats were induced by injection of steptozotocin(STZ).Rats were randomly divided into three groups:control group,diabetic model group,and LMWH treatment group.The levels of total cholesterol(TC),triglyceride(TG),prothrombin time(PT),kaolin partial thromboplastin time(KPTT),24-hour urinary albumin excretion rate(UAER),and serum soluble P-selectin were determined after 8 weeks.Glomerular morphology was observed by light microscopy.Results The levels of TG,UAER,and P-selectin in LWMH treatment group were lower than those in model group(all P<0.01).The levels of PT and KPTT in LWMH treatment group were shorter than those in model group.And LWMH improved the histological changes of diabetic rats.Conclusion LMWH has some renal protective effects in diabetic rats,partly through down-regulating the expression of P-selectin.
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页码：66 / 70
页数：5
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