Neuroprotective effects of vagus nerve stimulation on traumatic brain injury

被引：0
|
作者：
Long Zhou [1 ,2 ]
Jinhuang Lin [1 ,2 ]
Junming Lin [1 ,2 ]
Guoju Kui [1 ,2 ]
Jianhua Zhang [3 ]
Yigang Yu [1 ,2 ]
机构：
[1] Affiliated Dongnan Hospital of Xiamen University
[2] the 175 Hospital of Chinese PLA,Trauma Neurosurgery Center of Nanjing Military Region
[3] The 73131 Corps of Chinese PLA
来源：
Neural Regeneration Research | 2014年 / 9卷 / 17期
关键词：
nerve regeneration; brain injury; vagus nerve stimulation; tumor necrosis factor-α; interleukin-1β; interleukin-10; brain tissue pathology; protection; explosive injury; mechanisms; hydrocephalus; neural regeneration;
D O I：
暂无
中图分类号：
R651.1 [颅脑];
学科分类号：
1002 ; 100210 ;
摘要：
Previous studies have shown that vagus nerve stimulation can improve the prognosis of traumatic brain injury. The aim of this study was to elucidate the mechanism of the neuroprotective effects of vagus nerve stimulation in rabbits with brain explosive injury. Rabbits with brain explosive injury received continuous stimulation(10 V, 5 Hz, 5 ms, 20 minutes) of the right cervical vagus nerve. Tumor necrosis factor-α, interleukin-1β and interleukin-10 concentrations were detected in serum and brain tissues, and water content in brain tissues was measured. Results showed that vagus nerve stimulation could reduce the degree of brain edema, decrease tumor necrosis factor-α and interleukin-1β concentrations, and increase interleukin-10 concentration after brain explosive injury in rabbits. These data suggest that vagus nerve stimulation may exert neuroprotective effects against explosive injury via regulating the expression of tumor necrosis factor-α, interleukin-1β and interleukin-10 in the serum and brain tissue.
引用
收藏
页码：1585 / 1591
页数：7
相关论文
共 50 条
  • [1] Neuroprotective effects of vagus nerve stimulation on traumatic brain injury
    Zhou, Long
    Lin, Jinhuang
    Lin, Junming
    Kui, Guoju
    Zhang, Jianhua
    Yu, Yigang
    [J]. NEURAL REGENERATION RESEARCH, 2014, 9 (17) : 1585 - 1591
  • [2] Scope for Vagus Nerve Stimulation in Traumatic Brain Injury
    Kumaria, Ashwin
    Tolias, Christos M.
    [J]. NEUROMODULATION, 2021, 24 (06): : 1135 - 1136
  • [3] Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury
    Chiluwal, Amrit
    Narayan, Raj K.
    Chaung, Wayne
    Mehan, Neal
    Wang, Ping
    Bouton, Chad E.
    Golanov, Eugene V.
    Li, Chunyan
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [4] Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury
    Amrit Chiluwal
    Raj K. Narayan
    Wayne Chaung
    Neal Mehan
    Ping Wang
    Chad E. Bouton
    Eugene V. Golanov
    Chunyan Li
    [J]. Scientific Reports, 7
  • [5] Is there a role for vagus nerve stimulation therapy as a treatment of traumatic brain injury?
    Kumaria, Ashwin
    Tolias, Christos M.
    [J]. BRITISH JOURNAL OF NEUROSURGERY, 2012, 26 (03) : 316 - 320
  • [6] Feasibility of Transcutaneous Vagus Nerve Stimulation in Patients with Severe Traumatic Brain Injury
    Hansen, Christian Pilebaek
    Moghiseh, Melika
    Oland, Christoffer
    Poulsen, Ingrid
    Sabers, Anne
    [J]. BRAIN INJURY, 2019, 33 : 150 - 150
  • [7] Effects and neuroprotective mechanisms of vagus nerve stimulation on cognitive impairment with traumatic brain injury in animal studies: A systematic review and meta-analysis
    Zhang, Han
    Li, Chun-liu
    Qu, Yun
    Yang, Yu-xuan
    Du, Juan
    Zhao, Yu
    [J]. FRONTIERS IN NEUROLOGY, 2022, 13
  • [8] Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury
    Daniel Neren
    Matthew D. Johnson
    Wynn Legon
    Salam P. Bachour
    Geoffrey Ling
    Afshin A. Divani
    [J]. Neurocritical Care, 2016, 24 : 308 - 319
  • [9] Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury
    Neren, Daniel
    Johnson, Matthew D.
    Legon, Wynn
    Bachour, Salam P.
    Ling, Geoffrey
    Divani, Afshin A.
    [J]. NEUROCRITICAL CARE, 2016, 24 (02) : 308 - 319
  • [10] Transcutaneous Vagus Nerve Stimulation in Patients With Severe Traumatic Brain Injury: A Feasibility Trial
    Hakon, Jakob
    Moghiseh, Melika
    Poulsen, Ingrid
    Oland, Christoffer M. L.
    Hansen, Christian P.
    Sabers, Anne
    [J]. NEUROMODULATION, 2020, 23 (06): : 859 - 864
12345