Ketamine-induced peripheral analgesia in rats

被引：0
|
作者：
柏李 [1 ]
赵志奇 [1 ]
机构：
[1] 中国科学院上海脑研究所
来源：
Acta Pharmacologica Sinica | 1997年 / 04期
关键词：
氯氨酮; 电刺激; 肌电描记术; 测痛; 镇痛; 纳络酮;
D O I：
暂无
中图分类号：
R971.2 [];
学科分类号：
1007 ;
摘要：
目的：研究氯氨酮是否可以直接作用于外周伤害性感受器而产生镇痛．方法：一对不锈钢针插入尿酯麻醉的大鼠一侧后肢的两足脂皮下，施加强电流（２ｍｓ，８０Ｖ，２－３脉冲，０５Ｈｚ）作为伤害性刺激，在同一后肢的后二头半腱肌记录肌电反应，电刺激引起的长潜伏期Ｃ成分，作为伤害性屈反射的指标．结果：在邻近刺激电极的跖部皮下注射氯氨酮（３６ｍｍｏｌ·Ｌ－１，５μＬ）可明显抑制Ｃ反应，注射氯氨酮后９分钟，在同一部位注射５μＬ的１％纳络酮，可翻转抑制效应．结论：氯氨酮可直接作用外周伤害性感受器产生镇痛，并提示可能与外周阿片受体的激活有关．
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页数：3
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