Repetitive,Low-dose Tissue Plasminogen Activator for Clearance of Experimental Vitreous Hemorrhage

被引：0

作者：

Peiquan ZhaoWenji WangHouyan SongYunsong ZhuDept of OphthalmologyEye ENT HospitalShanghai Medical University Shanghai China ^{[200031
]}

机构：

来源：

眼科学报 | 1995年 / 01期

关键词：

tissue-type plasminogen activaltor; vitreous hemorrhage; retinal detachment; animal laboratory; intralesional injections; toxicity;

D O I：

暂无

中图分类号：

R770.2 [];

学科分类号：

摘要：

<正> Purpose:To investigate the effectiveness of repetitive,low-dose tPA for clearance of experimental vitreous hemorrhage.Methods :The model vitreous hemorrhage was produced by intravitreal injection of 0. 05ml of autologous citrated whole blood in 14 rabbits (28 eyes). One week after the creation of vitreous hemorrhage,the eyes were randomly separated into 3 groups. Groups 1 and 2 received two injections of 5 or 25μg of tPA,respectively, with one injection in a 7-day interval. Group 3 received two injections of PS in the same way.Results:The clearance of vitreous hemorrhage in tPA-treated groups was significantly faster than that in the control group (P<0. 05, or P<0. 01). However, there was no statistically significant difference between the two tPA-treated groups. Not any retinal toxicity was detected by ERG, light microscopy, and transmission electron microscopy examinations.Conclusions: Repetitive injections of low-dose tPA were effective in the treatment of experimental vitreous hemorrhage. Whether i

引用

页码：29 / 31+40 +40

页数：4

共 4 条

[1] Min WK.Kim YB:Resolution of experimental intravitreal fibrin by tissue plasminogen activator. Korean Journal of Ophthalmology . 1990
[2] Sternberg P Jr,Aguilar HE,Drews C,et al.The effect of tissue plasminogen activator.on retinal bleeding. Archives of Ophthalmology . 1990
[3] Min WK,Kim YB,Ahn BH:Repetitive.low-dose tissue plasminogen activator for clearance of ex perimental vitreous hemorrhage. Investigative Ophthalmology . 1991
[4] Min WK,Kim YB.Lee KM:Treatment of experimental vitreous hemorrhage with tissue plasminogen activetor. Korean Journal of Ophthalmology . 1990

← 1 →