Simultaneous determination of borneol and its metabolite in rat plasma by GC-MS and its application to pharmacokinetic study

被引：1
|
作者：
Xiu-Man Sun [1 ]
Qiong-Feng Liao [1 ]
Yu-Ting Zhou [2 ]
Xue-Jiao Deng [2 ]
Zhi-Yong Xie [2 ]
机构：
[1] School of Chinese Materia Medica,Guangzhou University of Chinese Medicine
[2] School of Pharmaceutical Sciences,Sun Yat-sen University
来源：
Journal of Pharmaceutical Analysis | 2014年 / 4卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Borneol; Camphor; Simultaneous determination; Pharmacokinetics; GC-MS;
D O I：
暂无
中图分类号：
R285.5 [中药实验药理];
学科分类号：
1008 ;
摘要：
A gas chromatography mass spectrometry(GC-MS) method has been developed and fully validated for the simultaneous determination of natural borneol(NB) and its metabolite,camphor,in rat plasma.Following a single liquid-liquid extraction,the analytes were separated using an HP-5MS capillary column(0.25 mm × 30 m × 0.25 μm) and analyzed by MS in the selected ion monitoring mode.Selected ion monitor(m/z) of borneol,camphor and internal standard was 95,95 and 128,respectively.Linearity,accuracy,precision and extraction recovery of the analytes were all satisfactory.The method was successfully applied to pharmacokinetic studies of NB after oral administration to Wistar rats.
引用
收藏
页码：345 / 350
页数：6
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